TUNG-MING TSAIWAN-TING HUNGMONG-WEI LINHSAO-HSUN HSUJIN-SHING CHEN2019-11-182019-11-182019-040929-6646https://scholars.lib.ntu.edu.tw/handle/123456789/431386Purpose: Uniportal video-assisted thoracoscopic surgery (VATS) has recently been reported as an alternative to conventional VATS. However, preoperative image-guided localization is usually required for small nodules. The present study evaluated the efficacy of preoperative computed tomography-guided dye localization prior to uniportal VATS for small undetermined pulmonary nodules. Methods: We retrospectively reviewed 298 consecutive patients who underwent uniportal VATS to treat undetermined pulmonary nodules (diameter ≤ 1.5 cm). Propensity score matching incorporating preoperative parameters was used to reduce the selection bias in a 1:1 manner. Comprehensive data including clinical features and perioperative variables were compared to evaluate the efficacy of preoperative computed tomography (CT)-guided dye localization prior to uniportal VATS. Results: A total of 232 patients received preoperative CT-guided dye localization (localization group) and 66 did not (direct surgery group), and the propensity score matching analysis generated 55 pairs of patients in both groups. The demographics and operative outcomes, including clinical nodule size, depths of the nodule, were comparable for both groups. The complication rates were low in both groups (3.6% and 1.8%, respectively). The uniportal to multi-portal VATS conversion rate was significantly higher in the direct surgery group than in the localization group (12.7% vs 1.8%, P = 0.030). 5 cases were converted due to failure in tumor identification (7.3% vs 1.8%, P = 0.182). Conclusion: Uniportal VATS is a feasible, effective, and safe procedure for the treatment of undetermined pulmonary nodules. The use of preoperative computed tomography-guided dye localization may be associated with a lower risk of conversion of uniportal VATS.enPreoperative computed tomography-guided localization; Uniportal VATSUniportal VATS[SDGs]SDG3adult; anesthesia induction; Article; bleeding; clinical feature; computer assisted tomography; female; forced expiratory volume; forced vital capacity; human; length of stay; lobectomy; lung nodule; major clinical study; male; middle aged; minimally invasive procedure; morbidity; mortality; operation duration; perioperative period; preoperative evaluation; propensity score; respiratory tract intubation; retrospective study; segmentectomy; selection bias; surgical technique; thorax drainage; video assisted thoracoscopic surgery; wedge resection; aged; diagnostic imaging; evaluation study; intralesional drug administration; lung nodule; lung tumor; multiple pulmonary nodules; postoperative complication; predictive value; preoperative care; treatment outcome; x-ray computed tomography; coloring agent; disulfine blue; fuchsine; Aged; Coloring Agents; Female; Humans; Injections, Intralesional; Lung Neoplasms; Male; Middle Aged; Multiple Pulmonary Nodules; Postoperative Complications; Predictive Value of Tests; Preoperative Care; Propensity Score; Retrospective Studies; Rosaniline Dyes; Solitary Pulmonary Nodule; Thoracic Surgery, Video-Assisted; Tomography, X-Ray Computed; Treatment Outcomejournal article10.1016/j.jfma.2018.09.002302370412-s2.0-85053683249WOS:000464349300006https://api.elsevier.com/content/abstract/scopus_id/85053683249