VIVIAN LIAO2020-01-142020-01-1420180021-8561https://scholars.lib.ntu.edu.tw/handle/123456789/449129There is growing need and interest in finding specific compounds in natural products that have health benefits. Despite ongoing efforts to discover such compounds, the scientific evidence lags behind the vision, and it is important to find an effective paradigm for discovering such compounds. The model organism Caenorhabditis elegans offers a promising solution for studying the potential bioactivity and molecular mechanisms of natural compounds in vivo. This perspective discusses its use to study potential human health benefits, with focus on antioxidative, anti-aging, antimetabolic disorders (diabetes and obesity), and antineurodegenerative activities (Alzheimer's disease and Parkinson's disease), with practical examples. Finally, future directions in using a C. elegans-based model for discovering bioactive compounds for health promotion are discussed. ? 2018 American Chemical Society.bioactivity; Caenorhabditis elegans; health benefits; in vivo; natural compounds[SDGs]SDG3Bioactivity; Neurodegenerative diseases; Alzheimer's disease; Bioactive compounds; Caenorhabditis elegans; Health benefits; In-vivo; Natural compounds; Parkinson's disease; Scientific evidence; Health; antidiabetic agent; antioxidant; biological product; aging; animal; Caenorhabditis elegans; disease model; drug effects; human; physiology; Aging; Animals; Antioxidants; Biological Products; Caenorhabditis elegans; Disease Models, Animal; Humans; Hypoglycemic Agentsjournal article10.1021/acs.jafc.7b057002-s2.0-85042649252https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85042649252&doi=10.1021%2facs.jafc.7b05700&partnerID=40&md5=cdc7bb94086b823e79b6e4f5860830de