Liao, S.-H.S.-H.LiaoLiu, C.-H.C.-H.LiuBastakoti, B.P.B.P.BastakotiSuzuki, N.N.SuzukiChang, Y.Y.ChangYamauchi, Y.Y.YamauchiLin, F.-H.F.-H.LinKEVIN CHIA-WEN WUFENG-HUEI LIN2020-02-262020-02-262015https://scholars.lib.ntu.edu.tw/handle/123456789/463923Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fuid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic feld, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems. ? 2015 Liao et al.[SDGs]SDG3alginic acid; galactosamine; iron oxide; nanomaterial; superparamagnetic iron oxide nanoparticle; alginic acid; ferric ion; ferric oxide; glucuronic acid; hexuronic acid; nanoparticle; aqueous solution; Article; biocompatibility; cell transport; controlled study; hepatocellular carcinoma cell line; human; human cell; hyperthermia; in vitro study; infrared spectroscopy; magnetic field; particle size; precipitation; scanning electron microscopy; surface property; thermogravimetry; X ray diffraction; blood clotting; chemistry; drug delivery system; drug effects; fever; Hep-G2 cell line; procedures; temperature; Alginates; Blood Coagulation; Chemical Precipitation; Drug Delivery Systems; Ferric Compounds; Fever; Galactosamine; Glucuronic Acid; Hep G2 Cells; Hexuronic Acids; Humans; Magnetic Fields; Microscopy, Electron, Scanning; Nanoparticles; Spectroscopy, Fourier Transform Infrared; Temperature; Thermogravimetry; X-Ray Diffractionjournal article10.2147/IJN.S687192-s2.0-84929448713https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929448713&doi=10.2147%2fIJN.S68719&partnerID=40&md5=f3f15a1920c0e7a3b287966e97903797