2014-01-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/656857摘要：為提升國家競爭力，本計畫以推動整合型計畫進行研究之模式進行，規劃以集中發展五個關鍵領域和三種應用技術為主。2008年依據 2006年「幹細胞研發重點策略藍圖計畫」而提出發展重點，包含五個關鍵領域：（1）幹細胞的分離，培養與分化技術、（2）幹細胞的表現機制與流程控制、（3）後生性遺傳(epigenetic)調節與體細胞核核轉移的技術研發（4）動物移植模型、生醫奈米、與組織工程相關技術的建置（5）「誘導式多能性幹細胞(iPS cells)」相關之分析研究，及三種應用技術：（1）異體移植模型、（2）藥物研發及（3）細胞治療的試驗。接著在 2010 年幹細胞工作小組第二次會議討論出最新的幹細胞研究方向：（1）胚胎幹細胞、（2）多潛能(特定組織)的間葉幹細胞、（3）成體幹細胞、（4）生殖幹細胞、（5）重編程、分化及形態發生、（6）組織工程、（7）活體影像技術（電腦斷層磁振造影、正子斷層掃描追蹤幹細胞）、（8）癌症幹細胞。 本計畫目標為有效整合不同領域幹細胞研究相關的人力與資源，提升研究團隊水準，於 2007 年起推動七件整合型幹細胞及再生醫學研究旗艦計畫，依據以上提出的重點，進行具國際競爭力核心領域的研發。七件旗艦計畫於 2011 年10月執行期滿，本計畫辦公室於 2011 年 7月邀請國內外相關領域傑出研究學者組成諮詢委員會，評鑑期滿的旗艦計畫研究成果。之後依訂定之期程徵求下一期「前瞻計畫」構想書、計畫書，在 2011 年七月底完成前瞻計畫決選會議，並於2011年 10月 1日開始實行。前瞻計畫將於 103 年 9月期滿，因此今年計畫辦公室工作重心為徵求下一期的研究計畫、管考計畫進度及品質，同時協助推動國際合作計畫。<br> Abstract: The project aims to promote stem cell research in Taiwan by fully organizing domestic research experts and resources. To proper allocate research resources to achieve our mission, we will support five to six research groups in five key research topics. The proposed five research focuses are (1)The culture and differentiation of stem cell, (2) Mechanisms and pathways control of stem cells, (3) Epigenetic regulation and nuclear transfer (4) Animal model for transplantation, biomedical nanotechnology, and tissue engineering, and (5) Induced pluripotent stem cell (iPS). Three applied technologies with special emphases: (1) Xenotransplantation models, (2) Drug discovery and development, (3) Clinical trial on stem cell therapy. We also chose 8 important areas for future research: (1) embryonic stem cells, (2) pluripotent and mesenchymal stem cells in specific tissues, (3) adult stem cells, (4) germline stem cells, (5) reprogramming, differentiation and morphogenesis, (6) tissue engineering, (7) in vivo imaging techniques (MRI, CT applied on tracking stem cells), and (8) cancer stem cells. In order to integrate human resources and research facilities, we supported seven Stem cell and Regenerative Medicine Flagship research programs from 2007 to September 2011. These research teams have achieved a remarkable progress. Started in October 2011, five Stem Cell and Regenerative Medicine Frontier Research Programs granted by NSC were launched. This year, the specific aims for this office are (1) to call for new proposals, (2) to inspect research performance and quality of the flagships every season, to held a board meetings to discuss future stem cell research direction, and (3) to assistant potential international cooperations with leading research groups in the world.