Lin Y.-S.Tang C.-H.Yang C.-Y.C.Wu L.-S.Hung S.-T.HSIAO-LIN HWAChu P.-H.2020-02-032020-02-032011https://scholars.lib.ntu.edu.tw/handle/123456789/453037There is no large-scale population-based study to clarify the association between major adverse cardiovascular events (MACEs) and pre-eclampsia/eclampsia. A population-based Taiwanese cohort study was performed in 1,132,064 parturients from 1999 to 2003 using a dataset linking birth certificates and National Health Insurance hospital discharge data. Sociodemographic factors and obstetric complications were used in multivariate logistic regression models to determine adjusted hazard ratios of pre-eclampsia/eclampsia on risks of MACEs and mortality during pregnancy to at least the third year postpartum. Incidence rates of MACEs and all maternal mortality in women with pre-eclampsia/eclampsia were 16.21 and 40.38 per 100,000 patients per year, respectively. Women with pre-eclampsia/eclampsia had a 13.0-fold higher incidence of myocardial infarction, a 8.3-fold higher incidence of heart failure, a 14.5-fold higher incidence of stroke, a 12.6-fold higher incidence of MACEs, a 7.3-fold higher incidence of MACEs without stroke, a 2.3-fold higher incidence of MACE-related deaths, and a 6.4-fold higher incidence of overall death than women without pre-eclampsia/eclampsia. Kaplan-Meier survival curve discriminated in MACEs, nonstroke MACEs, MACE related death and overall death. In conclusion, women with pre-eclampsia/eclampsia have a significantly higher risk of MACEs, especially myocardial infarction and stroke, during pregnancy and their risk remains significant to <36 months postpartum. Our results suggest that women with pre-eclampsia/eclampsia should be closely monitored during pregnancy and for up to <3 years postpartum. ? 2011 Elsevier Inc. All rights reserved.[SDGs]SDG3adult; article; birth certificate; cardiovascular disease; cohort analysis; eclampsia and preeclampsia; female; hazard ratio; heart failure; heart infarction; human; incidence; Kaplan Meier method; major clinical study; maternal mortality; multivariate logistic regression analysis; obstetrics; pregnancy complication; priority journal; puerperium; stroke; Taiwan; cardiovascular disease; eclampsia; peripartum period; preeclampsia; pregnancy; retrospective study; risk factor; Taiwan; Adult; Cardiovascular Diseases; Eclampsia; Female; Humans; Incidence; Peripartum Period; Pre-Eclampsia; Pregnancy; Retrospective Studies; Risk Factors; Taiwan; Young Adultjournal article10.1016/j.amjcard.2010.08.0732-s2.0-78650871064