Tang J.Yeh Y.-C.Tai P.-T.YI-CHEUN YEH2019-09-262019-09-26200800092614https://scholars.lib.ntu.edu.tw/handle/123456789/425392Extending the Michaelis-Menten kinetic scheme, we consider a three-state diffusion-controlled reaction model to investigate the effects of fluctuating reaction rate on the blinking statistics of single-enzyme catalytic reactions. As a result of conformational changes, the barrier-height and the reaction rate for the bottleneck enzymatic reaction could fluctuate in time, leading to non-exponential blinking statistics. To illustrate model applications, some reported experimental data for single £]-galactosidase molecules were reanalyzed here to extract useful kinetic parameters. ? 2008 Elsevier B.V.journal article10.1016/j.cplett.2008.08.0092-s2.0-51349143911https://www2.scopus.com/inward/record.uri?eid=2-s2.0-51349143911&doi=10.1016%2fj.cplett.2008.08.009&partnerID=40&md5=8ae8d46ce42e64f9499e1b11900d409d