Huang, Miao-HuiMiao-HuiHuangChen, Guan-JhouGuan-JhouChenKUAN-YIN LINWANG-DA LIUSu, Li-HsinLi-HsinSuHSIN-YUN SUNCHIEN-CHING HUNG2025-07-092025-07-092025-06-14https://scholars.lib.ntu.edu.tw/handle/123456789/730647To better understand the burden of hepatitis C virus (HCV) infection among HIV-negative men who have sex with men (MSM) in Taiwan, we conducted a prospective surveillance study of HCV viremia and bacterial sexually transmitted infections (STIs) among users of pre-exposure prophylaxis (PrEP) for HIV. Between 2018 and 2024, a total of 603 individuals participated in the national PrEP program. The baseline HCV seroprevalence was 1.2%, and no incident cases of HCV viremia were observed among the 364 participants enrolled in this surveillance study with 311.58 person-years of follow-up, giving the upper limit of the 95% confidence interval estimated to be 0.96 per 100 person-years. In contrast, 69 episodes of bacterial STIs were recorded, corresponding to an incidence rate of 22.14 per 100 person-years, indicating ongoing high-risk sexual behaviors in this population. These findings underscore the need for continued surveillance and strengthened prevention strategies to advancing efforts toward HCV elimination.enHCV eliminationMen who have sex with menMicroeliminationPooled-plasma HCV RNA testingSexually transmitted infectionjournal article10.1016/j.jfma.2025.06.02140518340