2013-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/680302摘要：肥胖與許多代謝性疾病具有關聯性，其中包含糖尿病與心血管疾病等。子計劃3第一年目的為建立以西方飼糧誘發李宋豬產生代謝症侯群。本試驗以9月齡李宋豬為試驗模式，逢機分為2組，分別餵飼一般飼糧（C）或西方飼糧（W）為期5個月，試驗期間監測其體重與血液生化值，於試驗結束後予以犧牲並採集組織。結果顯示，W組之體重、背脂厚度與全身脂肪分布率皆顯著高於C組（P < 0.05）。血液中之血糖、三酸甘油酯與總膽固醇濃度皆以W組顯著較高（P < 0.05）。而於靜脈葡萄糖耐受性測試中，顯現出W組於試驗末期已產生葡萄糖不耐之徵狀。綜觀上述，長期餵飼李宋豬西方飼糧，確實增加豬隻體重與體脂肪堆積之表現，並造成高血糖、高血脂與葡萄糖不耐之代謝症候群反應。<br> Abstract: Obesity is associated with many metabolic diseases, including diabetes and cardiovascular diseases. The objective of year 1 for subproject 3 is to establish a Lee-Sung miniature pig model of Western diet-induced metabolic syndrome. In our study, 9-month-old miniature pigs were randomly assigned to 2 groups for 5-month experimental periods: control diet (C) and Western diet (W). The body weight and blood parameters were monitored during the experiment periods. At the end of the experiment, pigs were sacrificed and tissues were collected. The results shown that W group had higher body weight than the C group (P < 0.05). W group also had higher values in back fat thickness and body fat ratio (P < 0.05) than C group. Compare with C group, W group had an elevated level of blood glucose, triglyceride and total cholesterol (P < 0.05). Furthermore, results of intravenous glucose tolerance test show that W pigs had glucose intolerance in the end of experiment, while C pigs did not. In conclusion, long-term feeding Western diet to Lee-Sung miniature pigs not only increased the body weight and fat accumulation, but also induced the metabolic syndromes including hyperglycemia, hyperlipidemia and glucose intolerance.肥胖代謝症候群李宋豬葡萄糖不耐obesitymetabolic syndromeLee-Sung minipigglucose intorlance