Tsai, Hui-JenHui-JenTsaiChen, Ming-HuangMing-HuangChenHSIU-PO WANGHsiao, Chin-FuChin-FuHsiaoChen, Yen-YangYen-YangChenChen, Jen-ShiJen-ShiChenYang, Mei-DueMei-DueYangTzen, Chin-YuanChin-YuanTzenShan, Yan-ShenYan-ShenShanBai, Li-YaunLi-YaunBaiChan, De-ChuanDe-ChuanChanChu, Pei-YiPei-YiChuHo, Ching-LiangChing-LiangHoYang, YoungsenYoungsenYangLin, JohnsonJohnsonLinLin, Hsuan-YuHsuan-YuLinChang, Cheng-ShyongCheng-ShyongChangWang, Chuan-ChengChuan-ChengWangHwang, Tsann-LongTsann-LongHwangChen, Li-TzongLi-TzongChen2026-01-262026-01-262025-09-01https://www.scopus.com/pages/publications/105013801909?inwardhttps://scholars.lib.ntu.edu.tw/handle/123456789/735596Background: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) account for more than 50% of all NENs. The survival of patients with GEP-NENs has improved based on early diagnosis and improved treatment strategies. The real-world data of GEP-NENs in Taiwan are limited. A multicenter registry study was conducted to obtain real-world data on GEP-NENs in Taiwan. Methods: Patients with pathologically diagnosed GEP-NENs were enrolled. Data were on the baseline characteristics, treatment strategies, and patient survival. Also evaluated was the expression status of six biomarkers, including SSTR2, SSTR5, PDX-1, CDX-2, mASH1, and NeuroD, in tumors. Overall survival (OS) was analyzed and plotted via the Kaplan–Meier method. Cox regression analysis was used to analyze the prognostic factors of OS. Results: A total of 600 GEP-NEN patients were enrolled. Pancreatic NENs accounted for 43.0% of all patients. The 5-year and 10-year OS rates of all patients were 70.9% and 61.3%, respectively. In the multivariable Cox regression analysis, older age (hazard ratio [HR] = 1.02; 95% CI, 1.01–1.03), higher Eastern Cooperative Oncology Group performance status score, higher tumor grade (World Health Organization classification) and stage 4 disease (HR = 6.22; 95% CI, 3.60–10.76) were associated with poor OS. Positive SSTR2 expression (HR = 0.53; 95% CI, 0.31–0.91) was associated with better OS according to multivariate Cox regression analysis. Conclusions: This study provides real-world data on 600 GEP-NENs in Taiwan and identifies age, Eastern Cooperative Oncology Group performance status score, tumor grade, tumor stage, and SSTR2 expression as prognostic factors for the survival of GEP-NENs. © 2025 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.engastroenteropancreasneuroendocrine neoplasmprognostic factorregistry studysurvival[SDGs]SDG1journal article10.1002/cncr.7001940833160