Liu, CongCongLiuCai, JingJingCaiChen, RenjieRenjieChenSera, FrancescoFrancescoSeraGuo, YumingYumingGuoTong, ShiluShiluTongLi, ShanshanShanshanLiLavigne, EricEricLavigneCorrea, Patricia MatusPatricia MatusCorreaOrtega, Nicolas ValdesNicolas ValdesOrtegaOrru, HansHansOrruMaasikmets, MarekMarekMaasikmetsJaakkola, Jouni J KJouni J KJaakkolaRyti, NiiloNiiloRytiBreitner, SusanneSusanneBreitnerSchneider, AlexandraAlexandraSchneiderKatsouyanni, KleaKleaKatsouyanniSamoli, EvangeliaEvangeliaSamoliHashizume, MasahiroMasahiroHashizumeHonda, YasushiYasushiHondaNg, Chris Fook ShengChris Fook ShengNgDiaz, Magali HurtadoMagali HurtadoDiazla Cruz Valencia, César DeCésar Dela Cruz ValenciaRao, ShilpaShilpaRaoPalomares, Alfonso Diz-LoisAlfonso Diz-LoisPalomaresPereira da Silva, SusanaSusanaPereira da SilvaMadureira, JoanaJoanaMadureiraHolobâc, Iulian HoriaIulian HoriaHolobâcFratianni, SimonaSimonaFratianniScovronick, NoahNoahScovronickGarland, Rebecca MRebecca MGarlandTobias, AurelioAurelioTobiasÍñiguez, CarmenCarmenÍñiguezForsberg, BertilBertilForsbergÅström, ChristoferChristoferÅströmVicedo-Cabrera, Ana MariaAna MariaVicedo-CabreraRagettli, Martina SMartina SRagettliYUE-LIANG GUOPan, Shih-ChunShih-ChunPanMilojevic, AiAiMilojevicBell, Michelle LMichelle LBellZanobetti, AntonellaAntonellaZanobettiSchwartz, JoelJoelSchwartzGasparrini, AntonioAntonioGasparriniKan, HaidongHaidongKan2023-03-082023-03-082022-10-151073-449Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/629059Rationale: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%-0.84%), 0.43% (95% CI, 0.15%-0.71%), and 0.41% (95% CI, 0.06%-0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10.enPM2.5-10; air pollution; mortality; multicenter study; time-series studyjournal article10.1164/rccm.202111-2657OC356714712-s2.0-85140144957WOS:000871243100012https://api.elsevier.com/content/abstract/scopus_id/85140144957