Yang W.-CLin C.-YWEI-WEN LIUPAI-CHI LIHsu Y.-H.2021-09-022021-09-022019https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094981180&partnerID=40&md5=148113e9b784b38416dba76163e02452https://scholars.lib.ntu.edu.tw/handle/123456789/581539In this paper, we report a new microfluidic approach to stimulate both vasculogenic and angiogenic processes in one microfluidic chip. This microfluidic platform can first develop a vascularized microtissue by vasculogenic process in one microchamber followed by stimulating angiogentic sprouting process from these pre-existing vasculature and growing into an adjacent microchamber to form vessels in a stroma or tumor microtissue. Experimental results verified that angiogenic process and tumor-angiogenic process can be induced in this microfluidic platform. This design can provide a more realistic angiogenic vessel network for the application of drug delivery and organ-on-a-chip. ? 2019 CBMS-0001.Drug delivery; Microchannels; Tumors; Angiogenesis; Angiogenic process; Micro-chambers; Microfluidic chip; Microfluidic platforms; Vasculature; Vasculogenic; Vessel networks; Microfluidicsconference paper2-s2.0-85094981180