Huang, C.-Y.C.-Y.HuangAhmed, A.F.A.F.AhmedSu, J.-H.J.-H.SuSung, P.-J.P.-J.SungHwang, T.-L.T.-L.HwangChiang, P.-L.P.-L.ChiangCHANG-FENG DAILiaw, C.-C.C.-C.LiawSheu, J.-H.J.-H.Sheu2018-09-102018-09-102017http://www.scopus.com/inward/record.url?eid=2-s2.0-85021127830&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/400154Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (1–5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1–5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 1–6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils. ? 2017 Elsevier LtdAnti-inflammatory activity; Cytotoxicity; Sinularia brassica; Soft coral; Withanolide[SDGs]SDG3acetic acid ethyl ester; antiinflammatory agent; antineoplastic agent; elastase; sinubrasolide a; sinubrasolide h; sinubrasolide i; sinubrasolide j; sinubrasolide k; sinubrasolide l; superoxide; unclassified drug; withanolide; antiinflammatory agent; antineoplastic agent; cytochalasin B; pancreatic elastase; withanolide; antiinflammatory activity; Article; biological activity; cancer inhibition; cell proliferation; controlled study; coral; drug cytotoxicity; enzyme release; human; human cell; neutrophil; Sinularia brassica; animal; Anthozoa; chemistry; drug effects; immunology; isolation and purification; molecular model; Neoplasms; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cytochalasin B; Humans; Models, Molecular; Neoplasms; Neutrophils; Pancreatic Elastase; Superoxides; Withanolidesjournal article10.1016/j.bmcl.2017.06.0292-s2.0-85021127830WOS:000405106500011