NI-CHUNG LEEMING-JANG CHIU et al.Chieh J.-J.Huang P.-T.Chang L.-M.YEN-NAN CHIUHuang A.-C.YIN-HSIU CHIENWUH-LIANG HWUChiu M.-J.2020-11-032020-11-0320171663-4365https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012110510&doi=10.3389%2ffnagi.2016.00316&partnerID=40&md5=225e62b44ba7f1973b7464254d100f7chttps://scholars.lib.ntu.edu.tw/handle/123456789/519880: The Aβ-40 and Aβ-42 levels and the Aβ-42/Aβ-40 ratio are considered possible biomarkers for the early detection of degeneration in DS. The elevated Aβ-40 and tau levels in DS may indicate early neurodegeneration. The increased Aβ-42 in DS_D may reflect the neurotoxicity of Aβ-42. The paradox of the tau decreases in DS_D could be explained by a burnout phenomenon during long-term neurodegeneration. The different patterns of the plasma beta amyloids and tau protein may imply a different pathogenesis between DS with degeneration and AD in the general population, in spite of their common key pathological features.[SDGs]SDG3journal article10.3389/fnagi.2016.003162-s2.0-85012110510