PO-CHENG HSULiao K.-K.Lin K.-P.Chiu J.-W.Wu P.-Y.Chou C.-L.Wang N.-Y.Wang J.-C.2021-01-212021-01-2120200003-9993https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089146090&doi=10.1016%2fj.apmr.2020.06.018&partnerID=40&md5=d1774f4b7042a41456439e3d3bc03920https://scholars.lib.ntu.edu.tw/handle/123456789/541707Objectives: To evaluate whether the therapeutic effect of ultrasound-guided injections with 10 mg or 40 mg triamcinolone acetonide (TA) was dose-dependent in patients with idiopathic mild to moderate carpal tunnel syndrome (CTS). Design: Prospective, double-blind, randomized controlled study with 12 weeks of follow-up. Setting: Rehabilitation outpatient clinic of a single medical center. Participants: Patients with CTS (N=56). Intervention: Participants were randomly assigned to 2 treatment groups for injection: (A) 40 mg TA+2% lidocaine hydrochloride or (B) 10 mg TA+2% lidocaine hydrochloride. Main Outcome Measures: Participants were evaluated using visual analog scale (VAS) and Boston Carpal Tunnel Questionnaire (BCTQ, including Symptom Severity Scale [SSS] and Functional Status Scale [FSS]) at baseline and 6 and 12 weeks after injection). Nerve conduction studies, including parameters of distal motor latency, amplitude of compound motor action potential, amplitude of sensory nerve action potential and sensory nerve conduction velocity of median nerve, and the patient's subjective impression of improvement, were recorded before injection and 6 and 12 weeks after injection. Results: No significant differences were observed in baseline demographic characteristics and clinical evaluations. The parameters in group A and B at baseline, 6 weeks, and 12 weeks were (1) SSS: 2.17±0.14, 1.19±0.04, and 1.34±0.09 and 1.87±0.11, 1.21±0.07, and 1.26±0.04; (2) FSS: 1.63±0.07, 1.27±0.06, and 1.33±0.08 and 1.50±0.10, 1.18±0.05, and 1.26±0.05; (3) VAS: 6.4±0.3, 2.2±0.3, and 3.0±0.1 and 6.7±0.3, 2.0±0.3, and 3.1±0.3, respectively, and significantly decreased after 6 and 12 weeks in both treatment groups (P<.05). All parameters of nerve conduction studies improved in both groups after 12 weeks (P<.05). VAS, BCTQ, and nerve conduction studies did not show significant intergroup differences after 6 and 12 weeks. Conclusion: In patients with idiopathic mild to moderate CTS, ultrasound-guided injection with 10 and 40 mg TA yield similar improvements in BCTQ, VAS, and nerve conduction studies at the 12-week follow-up. ? 2020 American Congress of Rehabilitation MedicineCarpal tunnel syndrome; Randomized controlled trial; Rehabilitation; Triamcinolone acetonide[SDGs]SDG3lidocaine; triamcinolone acetonide; corticosteroid; lidocaine; triamcinolone acetonide; action potential; adult; Article; Carpal Tunnel Questionnaire; carpal tunnel syndrome; clinical evaluation; comparative study; controlled study; disease severity; disease severity assessment; double blind procedure; drug dose comparison; drug effect; female; follow up; functional status assessment; human; idiopathic disease; major clinical study; male; middle aged; prospective study; randomized controlled trial; sensory nerve conduction velocity; treatment duration; treatment outcome; visual analog scale; carpal tunnel syndrome; dose response; injection; interventional ultrasonography; median nerve; nerve conduction; pathophysiology; procedures; severity of illness index; Adrenal Cortex Hormones; Carpal Tunnel Syndrome; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections; Lidocaine; Male; Median Nerve; Middle Aged; Neural Conduction; Prospective Studies; Severity of Illness Index; Treatment Outcome; Triamcinolone Acetonide; Ultrasonography, Interventional; Visual Analog Scalejournal article10.1016/j.apmr.2020.06.018326829382-s2.0-85089146090