Hwu C.-M.Hsiao C.F.Grove J.Hung Y.J.LEE-MING CHUANGChen Y.T.Curb J.D.Chen Y.D.I.Rodriguez B.Ho L.T.2020-06-012020-06-0120070950-9240https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847062500&doi=10.1038%2fsj.jhh.1002137&partnerID=40&md5=48a47500b9f4dbff76b76121764c1891https://scholars.lib.ntu.edu.tw/handle/123456789/495706The purpose of the study is to compare surrogate estimates of insulin sensitivity with a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), in subjects with hypertension. Two hundred and twenty-eight hypertensive patients who received IST for SSPG were included for analysis. Estimates from fasting measurements alone, homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)), and indices from fasting and/or 2h samples (ISI0,120 and ISITX) were calculated. In addition to Pearson and partial correlations, variance-component models were used to test the relationship between surrogate estimates of insulin sensitivity and SSPG. A large proportion of variance owing to covariates in the variance-component models indicated the goodness of model fit, irrespective of the independence among variables. SSPG was positively correlated with logarithmic transformation (Log) (HOMA-IR) and negatively correlated with QUICKI, Log (ISI0,120) and ISITX (all P<0.0001). Log (ISI0,120) seemed to have a better correlation with SSPG (r=-0.72) than other measures in partial correlation. The proportion of variance owing to all covariates of Log (ISI0,120) and ISITX were larger than those of Log (HOMA-IR) and QUICKI in the variance-component models. After adjustments for demographic and obesity covariates, the proportion of variance explained by Log (ISI0,120) were largest among the surrogate measures in the variance-component models. Our results showed that ISI0,120 and ISITX correlated better with SSPG than those used fasting measures alone (HOMA-IR and QUICKI). Log (ISI0,120) currently showing the strongest association with SSPG than other estimates is adaptable for use in large studies of hypertension.[SDGs]SDG3angiotensin receptor antagonist; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; diuretic agent; glucose; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; isophane insulin; somatosan; somatostatin; taiyu; unclassified drug; adult; article; correlation coefficient; diabetes mellitus; diet restriction; female; glucose assay; glucose homeostasis; human; hypertension; impaired glucose tolerance; insulin infusion; insulin pump; insulin resistance; insulin sensitivity; insulin tolerance test; intermethod comparison; major clinical study; male; Adult; Analysis of Variance; Asian Continental Ancestry Group; Blood Glucose; Diabetes Mellitus; Female; Glucose Clamp Technique; Humans; Hypertension; Insulin; Insulin Resistance; Male; Middle Aged; Predictive Value of Tests; Sensitivity and Specificityjournal article10.1038/sj.jhh.1002137172302342-s2.0-33847062500