Wang C.-H.Wu K.-H.YUNG-LI YANGPeng C.-T.Wang R.-F.Tsai C.-W.Tsai R.-Y.Linn D.-T.Tsai F.-J.Bau D.-T.2021-01-062021-01-0620100250-7005https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958604385&partnerID=40&md5=3bdd833724ef3e0dc7de4b4686915d0bhttps://scholars.lib.ntu.edu.tw/handle/123456789/538664Aim: The relationship between COX-2 gene and childhood leukemia risk is ambiguous. In this study, the association of genotypic polymorphisms in cyclooxygenase 2 (Cox-2) with childhood leukemia were investigated. Materials and Methods: A total of 266 patients with childhood leukemia and 266 healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped by PCR-RFLP method. Six polymorphic variants of Cox-2 were investigated, including G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, and the associations of specific genotypes with susceptibility to childhood leukemia were analysed. Results: The data showed that although there was no difference in the distribution for each genotype of Cox-2 G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, between the childhood leukemia and control groups (p>0.05), the analysis of combined effect for COX-2 G-765C and intron 6 showed that individuals with GC at G-765C and GG or AG+AA at intron 6 present a slightly higher potential for developing childhood leukemia than other groups. Conclusion: These findings suggest that the C allele of COX-2 G-765C may be responsible for childhood leukemia and may be useful in early detection of child leukemia.Childhood leukemia; Cox-2; Polymorphism[SDGs]SDG3cyclooxygenase 2; cyclooxygenase 2; acute lymphoblastic leukemia; article; child; childhood leukemia; controlled study; female; genetic association; genotype; human; intron; major clinical study; male; preschool child; priority journal; school child; single nucleotide polymorphism; Taiwan; acute lymphoblastic leukemia; genetic predisposition; genetics; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism; Child; Cyclooxygenase 2; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Taiwanjournal article209441492-s2.0-77958604385