Wu Wen-ChauMohler III ERatcliffe S.JWehrli F.WDetre J.AFloyd T.F.2019-10-182019-10-1820090735-1097https://www.scopus.com/inward/record.uri?eid=2-s2.0-66949151329&doi=10.1016%2fj.jacc.2009.03.033&partnerID=40&md5=5baa6f58484a284e375dfec128d8071ehttps://scholars.lib.ntu.edu.tw/handle/123456789/426880Objectives: We present the novel application of continuous arterial spin-labeling (CASL) magnetic resonance imaging (MRI) for the measurement of calf muscle perfusion in subjects with progressive peripheral arterial disease (PAD). Background: Peripheral arterial disease is largely considered to be a disease of conduit vessels. The impact of PAD upon microvascular flow in the end-organ, muscle, remains unknown. Continuous arterial spin-labeling is a noninvasive MRI method capable of measuring microvascular flow and might assist in our understanding of the impact of PAD upon the microvasculature. Methods: Forty subjects with varying degrees of PAD and 17 age-matched PAD-free subjects were recruited and underwent measurement of the ankle-to-brachial index (ABI) and CASL. Peak hyperemic flow (PHF) and time-to-peak (TTP) were computed and assessed as a function of ABI and calf muscle group. Results: An ABI dependence was found in both PHF (p = 0.04) and TTP (p < 10-4). Whereas TTP increased almost immediately with increasing PAD severity, PHF was, in contrast, relatively well preserved until later stages of disease. Conclusions: The CASL flow measurements correlate with disease state as measured by ABI and demonstrate preserved microvascular flow reserve in the presence of early to intermediate vascular disease. ? 2009 American College of Cardiology Foundation.Englisharterial spin-labeling; magnetic resonance imaging; peripheral arterial disease; skeletal muscle[SDGs]SDG3adult; age distribution; aged; ankle brachial index; artery disease; blood flowmetry; clinical article; continuous arterial spin labeling; controlled study; disease course; female; gastrocnemius muscle; human; male; microvascularization; muscle blood flow; muscle perfusion; nuclear magnetic resonance imaging; priority journal; review; skeletal muscle; spin labeling; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Humans; Leg; Magnetic Resonance Angiography; Male; Microcirculation; Middle Aged; Muscle, Skeletal; Peripheral Vascular Diseasesreview10.1016/j.jacc.2009.03.033195391492-s2.0-66949151329