Lin H.T.-HChen J.-SNIEN-TSU HUANG2021-09-022021-09-022018https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079900566&partnerID=40&md5=c91a6f33d292a802c17564f5179d3257https://scholars.lib.ntu.edu.tw/handle/123456789/581070We designed a dual-mode microchannel integrating an automated microfluidic platform and localized surface plasmon resonance (LSPR) sensing for multi-parallel biomolecule detection. The platform consists of three components: (1) a four-channel microchannel, which can switch into the synchronized or independent modes based on different assay steps; (2) a microfluidic platform, which can automatically control all reagents flow; and (3) a LSPR spectroscopy system, which performs label-free, real-time, and multi-parallel detection of biomolecules at multiple sensing sites. Based on the above features, we believe that our platform can potentially be used for rapid multi-analyte biomolecule detection for timely disease diagnosis and treatments. Copyright ? (2018) by Chemical and Biological Microsystems Society. All rights reserved.Localized Surface Plasmon Resonance (LSPR); Microfluidics; Multi-parallel Biomolecule DetectionBiomolecules; Diagnosis; Microchannels; Microfluidics; Plasmons; Resonance; Biomolecule detection; Disease diagnosis; Independent mode; Localized surface plasmon resonance; Microfluidic platforms; Parallel detection; Reagents flows; Three component; Surface plasmon resonanceconference paper2-s2.0-85079900566