HSIN-YUN SUNSingh N.2020-12-292020-12-2920110306-9877https://www.scopus.com/inward/record.uri?eid=2-s2.0-79751538032&doi=10.1016%2fj.mehy.2010.09.019&partnerID=40&md5=7d007ae71842e250dd23f7d5975e2bcehttps://scholars.lib.ntu.edu.tw/handle/123456789/535393It has become evident that while a robust inflammatory response plays a critical role in eradicating invading microbes, dysregulated immunity can be detrimental to the host if an optimal balance between the inflammatory and anti-inflammatory reactions is disrupted. Opportunistic infection-associated immune reconstitution syndrome is characterized by an aggressive inflammatory immune response and its management remains challenging and largely unknown. Statins, in addition to their lipid lower effects have anti-inflammatory attributes and there is precedence for the use of these agents as a therapeutic modality for autoimmune inflammatory disorders which have similar underlying pathogenesis as immune reconstitution syndrome. We hypothesize that statins may have a potential role for the management of immune reconstitution syndrome. Our proposal has biologic and translational implications for optimizing outcomes in patients with immune reconstitution syndrome. ? 2010 Elsevier Ltd.[SDGs]SDG3antiinflammatory agent; gamma interferon; hydroxymethylglutaryl coenzyme A reductase inhibitor; interleukin 12; interleukin 1beta; interleukin 2; interleukin 6; thalidomide; tumor necrosis factor alpha; article; autoimmune disease; CD4+ T lymphocyte; genetic transcription; graft versus host reaction; human; immune reconstitution inflammatory syndrome; immunity; nonhuman; treatment outcome; Anti-Inflammatory Agents; Autoimmune Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune Reconstitution Inflammatory Syndrome; Inflammation; Opportunistic Infectionsjournal article10.1016/j.mehy.2010.09.01920965666