Tsai K.-C.YUNG-LI YANGPI-CHUAN FAN2020-12-212020-12-2120151875-9572https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943351707&doi=10.1016%2fj.pedneo.2013.04.002&partnerID=40&md5=61e27ce7ff8b8a75ca4b8f3cc4af8740https://scholars.lib.ntu.edu.tw/handle/123456789/529211Gabapentin is well known for its pain control and antiepileptic effect, but its antiemetic effect is poorly investigated. Here we report on effective gabapentin use for refractory vomiting after craniotomy in two children with medulloblastoma in the fourth ventricle. The two pediatric patients (an 11-year-old girl and a 4-year-old boy) underwent near-total excision of the tumor via craniotomy. Both patients suffered from refractory postoperative nausea and vomiting, treated with multiple traditional antiemetic drugs but without relief. After gabapentin intake, their nausea and vomiting improved from one to two episodes per day to complete resolution of symptoms. This report suggests that gabapentin may be a novel antiemetic therapeutic intervention for patients with refractory nausea and vomiting after craniotomy. Copyright ? 2015, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.[SDGs]SDG3domperidone; gabapentin; granisetron; metoclopramide; ondansetron; oxcarbazepine; topiramate; 4 aminobutyric acid; amine; amino acid receptor blocking agent; cyclohexanecarboxylic acid derivative; gabapentin; add on therapy; antiemetic activity; Article; brain fourth ventricle; brain third ventricle; cancer chemotherapy; cancer radiotherapy; cancer staging; cancer surgery; case report; child; childhood disease; computer assisted tomography; craniotomy; disease duration; drug efficacy; electroencephalography; female; follow up; human; intracranial hypertension; male; medulloblastoma; neuroimaging; nuclear magnetic resonance imaging; obstructive hydrocephalus; posterior cranial fossa tumor; postoperative nausea and vomiting; preschool child; recurrent disease; school child; adverse effects; Cerebellar Neoplasms; craniotomy; medulloblastoma; postoperative nausea and vomiting; Amines; Cerebellar Neoplasms; Child; Child, Preschool; Craniotomy; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Humans; Male; Medulloblastoma; Postoperative Nausea and Vomitingjournal article10.1016/j.pedneo.2013.04.002237644812-s2.0-84943351707