Chiu K.C.Chu A.LEE-MING CHUANGSaad M.F.2020-06-012020-06-0120040804-4643https://www.scopus.com/inward/record.uri?eid=2-s2.0-2942718557&doi=10.1530%2feje.0.1500725&partnerID=40&md5=5de4213cd20822b1b834168c327c2a41https://scholars.lib.ntu.edu.tw/handle/123456789/495637Objective: Although the role of the leptin receptor (LEPR) in obesity is well recognized, its role in insulin sensitivity remains unknown. Design: This was a cross-sectional study to investigate the impact of the Q223R polymorphism of the LEPR gene on insulin sensitivity. Methods: Sixty-seven glucose-tolerant Caucasians were enrolled. The insulin sensitivity index and glucose clearance were measured using a hyperglycemic clamp. Genomic DNA was extracted for genotyping. Results: We identified 20 QQ, 31 QR, and 16 RR subjects. The three genotypic groups were similar in age, gender distribution, body mass index, waist-hip ratio, and blood pressure, but differed in the insulin sensitivity index (P = 0.0180) and in glucose clearance (P = 0.0220). Multivariate analyses showed that the Q223R polymorphism was independently associated with the insulin sensitivity index (P = 0.0317) and glucose clearance (P = 0.0436). A trend of increasing low density lipoprotein cholesterol concentration was also observed (P = 0.0447). Conclusion: We have reported the first association of the Q223R polymorphism of the LEPR gene with insulin resistance. ? 2004 Society of the European Journal of Endocrinology.[SDGs]SDG3[SDGs]SDG5genomic DNA; glucose; insulin; leptin receptor; low density lipoprotein cholesterol; adult; age; anthropometry; article; blood pressure; body mass; Caucasian; controlled study; disease association; DNA extraction; female; genetic polymorphism; genotype; glucose tolerance; human; hyperglycemia; insulin resistance; insulin sensitivity; major clinical study; male; multivariate analysis; obesity; prevalence; priority journal; sex difference; Adult; Arginine; Cholesterol, LDL; Female; Genotype; Glucose; Glutamine; Humans; Insulin Resistance; Male; Multivariate Analysis; Polymorphism, Genetic; Receptors, Cell Surfacejournal article10.1530/eje.0.1500725151327312-s2.0-2942718557