C.-H. LiA.-H. LiaoPAI-CHI LIJA-AN ANNIE HO2018-09-102018-09-102005-09-18http://scholars.lib.ntu.edu.tw/handle/123456789/318090https://www.scopus.com/pages/publications/33847103622?origin=resultslistPulse inversion based fundamental imaging was proposed for the enhancement of contrast detection in a previous study. Performance of the imaging method was tested with a commercial contrast agent (Levovist®) at 1.5-3 MHz. In this study, we applied pulse inversion fundamental imaging at 25-50 MHz with liposome microbubbles that were produced in-house. The pulse inversion technique involves two firings with inverted waveforms. Because the reaction of the bubbles under compression is different from that under rarefaction, the signal in the fundamental band is used to enhance the contrast-to-tissue ratio. Phantom experiments were performed. Liposome microbubbles were made in-house with a recipe developed in our lab. Compared to conventional fundamental imaging, the contrast-to-tissue ratio was enhanced by 7~18 dB when the transmit signal was at 25~50MHz. Compared to the conventional second harmonic imaging, the pulse inversion fundamental imaging provides an additional advantage. That is, the bandwidth of the transmit signal is not limited to accommodate both the fundamental and harmonic bands within the passband of the transducer. With this technique, the microbubbles can be combined with ligands for small animal molecular imaging.enUltrasonic imagingPulse invertersResonant frequencyResonanceTestingAnimalsHigh-resolution imagingChemistryImaging phantomsBandwidth[SDGs]SDG7conference paper10.1109/ULTSYM.2005.16029292-s2.0-33847103622