Nguyen M.H.Husain S.Clancy C.J.Peacock J.E.CHIEN-CHING HUNGKontoyiannis D.P.Morris A.J.Heath C.H.Wagener M.Yu V.L.2021-12-012021-12-0120100163-4453https://www.scopus.com/inward/record.uri?eid=2-s2.0-78149358512&doi=10.1016%2fj.jinf.2010.08.004&partnerID=40&md5=e015cefdef8268df798e4c1833cc7b5bhttps://scholars.lib.ntu.edu.tw/handle/123456789/588881Background: Central nervous system (CNS) cryptococcosis is most commonly encountered among HIV-infected and other immunosuppressed hosts but is less well-characterized among non-immunosuppressed patients. Methods: We conducted a three year, prospective, observational study to compare the clinical manifestations and outcome of CNS cryptococcosis in three patient populations: HIV-infected patients (n = 54), HIV-negative immunosuppressed patients (n = 21), and non-immunosuppressed patients (n = 11). Results: Time from initial symptoms to presentation did not differ between the groups. HIV-infected patients were significantly more likely to present with fevers (p < 0.0001), but were less likely to have abnormal mental status, CNS mass lesions and pulmonary involvement (p = 0.001, 0.01 and 0.03, respectively). The clinical manifestations among HIV-negative immunosuppressed patients were generally intermediate to the other groups. Overall, acuity of illness was worse among non-immunosuppressed patients, as measured by APACHE II scores (p = 0.02). Intracranial pressure was higher in HIV-infected and non-immunosuppressed patients than immunosuppressed patients (p = 0.008 and 0.01, respectively). Repeated lumbar punctures were more common among HIV-infected patients (p = 0.01). There was a trend toward more frequent placement of permanent CNS shunts among non-HIV patients (p = 0.05). The mortality rate was greatest for non-immunosuppressed patients (p = 0.04). Conclusion: CNS cryptococcosis in non-immunosuppressed patients was associated with poorer prognosis. Our findings suggest that host immune responses may contribute to pathogenesis of CNS cryptococcosis, with more intact immune function associated with increased CNS-related morbidity and overall mortality. ? 2010 The British Infection Society.[SDGs]SDG3amphotericin B; amphotericin B lipid complex; antiretrovirus agent; corticosteroid; fluconazole; flucytosine; adult; APACHE; article; central nervous system infection; clinical feature; comparative study; controlled study; cryptococcosis; fever; high risk population; highly active antiretroviral therapy; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; immune deficiency; immune response; immunopathogenesis; immunosuppressive treatment; intracranial hypertension; lumbar puncture; major clinical study; mental health; morbidity; mortality; observational study; outcome assessment; prognosis; prospective study; pulmonary cryptococcosis; shunting; Adult; Antifungal Agents; APACHE; Australia; CD4 Lymphocyte Count; Central Nervous System Fungal Infections; Cerebrospinal Fluid Shunts; Cryptococcosis; Cryptococcus; HIV Infections; Humans; Immunocompetence; Immunocompromised Host; Middle Aged; Prognosis; Prospective Studies; Survival Analysis; Taiwan; Treatment Outcome; United Statesjournal article10.1016/j.jinf.2010.08.004207323502-s2.0-78149358512