Sato, MasaakiMasaakiSatoSHUN-MAO YANGTian, DongDongTianJun, NakajimaNakajimaJunJANG-MING LEE2021-11-262021-11-262021-052218-6751https://scholars.lib.ntu.edu.tw/handle/123456789/587934The broad application of low-dose computed tomography (CT) screening has resulted in the detection of many small pulmonary nodules. In Asia, a large number of these detected nodules with a radiological ground glass pattern are reported as lung adenocarcinomas or premalignant lesions, especially among female non-smokers. In this review article, we discuss controversial issues and conditions involving these subsolid pulmonary nodules that we often face in Asia, including a lack or insufficiency of current guidelines; the roles of preoperative biopsy and imaging; the location of lesions; appropriate selection of localization techniques; the roles of dissection and sampling of frozen sections and lymph nodes; multifocal lesions; and the roles of non-surgical treatment modalities. For these complex issues, we have tried to present up-to-date evidence and our own opinions regarding the management of subsolid nodules. It is our hope that this article helps surgeons and physicians to manage the complex issues involving ground glass nodules (GGNs) in a balanced manner in their daily practice and provokes further discussion towards better guidelines and/or algorithms.enLung cancer screening; localization; sublobar resection; subsolid nodules[SDGs]SDG3adult; algorithm; Asian; cancer screening; cancer surgery; case report; clinical article; conservative treatment; dissection; female; frozen section; ground glass opacity; high risk patient; human; intraoperative period; low-dose computed tomography; lung adenocarcinoma; lung cancer; lung lobectomy; lung nodule; lymph node; lymph node dissection; male; mediastinum lymph node; microwave thermotherapy; middle aged; non-smoker; practice guideline; preoperative evaluation; radiofrequency ablation; Review; stereotactic body radiation therapy; tumor volume; wedge resectionjournal article10.21037/tlcr-20-243341642802-s2.0-85106913794https://api.elsevier.com/content/abstract/scopus_id/85106913794