2010-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/649604摘要：頭頸部動脈剝離占年輕型腦中風病患的20%，是年輕與中年成人中風病患的少見但相當重要的病因。然而頭頸部動脈剝離可能的發生原因及致病機轉目前仍然缺乏整合性的研究。本計畫預計於三年內從台灣中風登錄計畫的各醫院收錄150 位頭頸部動脈剝離的急性中風病患及150 位慢性中風病患，以及年齡、性別相符的健康對照組。急性中風個案在發病後一週內、三個月及一年後接受腦血流自動控制功能檢查、血栓偵測、電腦斷層血管攝影及抽血等評估。慢性中風個案則接受一次腦血流自動控制功能檢查、血栓偵測、電腦斷層血管攝影及抽血等評估。並登錄病患急性期及發病後1 個月、3 個月、6個月以及1 年的神經功能預後。血液檢體在分離出DNA 後將進行全基因體掃瞄研究。本研究將探討：(1) 頭頸部動脈剝離病患的腦血流自動控制能力及血栓偵測檢查與中風表現及預後的相關性；（2）全基因體掃瞄研究尋找頭頸部動脈剝離相關的基因方面的危險因子。研究目標(第一年)：收集急性及慢性頭頸部動脈剝離引起腦中風的病患。預計第一年收錄五十位急性中風及五十位慢性中風個案，並開始神經超音波及電腦斷層血管攝影等檢查。研究目標(第二年)：持續收集頭頸部動脈剝離引起腦中風的病患，並開始進行全基因體掃瞄研究。研究目標(第三年)：完成急性中風一百五十位，慢性中風一百五十位及年齡性別相符的健康對照組的收案目標，並根據全基因體掃瞄研究分析相關的危險因子。<br> Abstract: Cervicocerebral arterial dissections occur in 1-2% of strokes, and they are one of themajor causes of stroke in the young and middle-aged patients. So far, there were only a fewstudies regarding the risk factors and pathogenesis of cervicocerebral arterial dissections. Ourstudy aims to recruit 300 (acute, 150; chronic, 150) stroke patients diagnosed ascervicalcerebral arterial dissection as well as age-sex matched healthy controls from hospitalsparticipating in Taiwan Stroke Registry. For patients with acute stroke, cerebralautoregulation evaluation, emboli detection, CT angiography and blood drawing will beperformed within 1 week, 3 months and 1 year after stroke. For patients with chronic stroke,cerebral autoregulation evaluation, emboli detection, CT angiography and blood drawing willbe performed once. Neurological functional status at acute stage, 1, 3, and 6 months and 1year after stroke will be regularly followed. DNA will be extracted from the blood samplesand will be used for genome-wide survey.Our study will investigate if (1) the status of cerebral autoregulation and embolidetection exams correlate well with the stroke presentations and functional outcome (2) anygenetic risk factor for spontaneous cervicocerebral artery dissections from the genome-widesurvey.Specific aims (first year):Recruit at least 50 patients with acute stroke and 50 patients with chronic stroke due tocervicocerebral arterial dissections and perform cerebral autoregulation, emboli detection andCT angiography exams.Specific aims (second year):Keep recruiting stroke patients with cervicocerebral arterial dissections and performing theaforementioned exams. Start genome-wide survey for the recruited subjectsSpecific aims (third year):Complete recruitment of patients and normal controls and analyze the genetic risk factors forcervicocerebral artery dissections.