JULIA YU-FONG CHANGCHUN-PIN CHIANGCHUHSING KATE HSIAOANDY SUN2021-10-152021-10-1520090904-2512https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149163423&doi=10.1111%2fj.1600-0714.2008.00686.x&partnerID=40&md5=cef610582b3bfa0f39055417d8cd40d7https://scholars.lib.ntu.edu.tw/handle/123456789/584881Background: Previous studies have shown the presence of serum anti-nuclear (ANA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA) and anti-thyroid microsomal autoantibodies (TMA) in small groups of patients with oral lichen planus (OLP). Methods: In this study, the serum levels of ANA, SMA, AMA, GPCA, TGA and TMA were measured in a group of 320 Chinese OLP patients and 53 healthy control subjects to assess whether Chinese OLP patients had significantly higher frequencies of serum autoantibodies than healthy control subjects and to assess which risk factors had a significant influence on the possession of a specific serum autoantibody in OLP patients. Results: We found that autoantibodies were present in 195 (60.9%) of the 320 OLP patients. The frequencies of presence of serum ANA (28.1%), GPCA (26.3%), TGA (21.3%) and TMA (24.4%) in OLP patients were significantly higher than those (5.7%, 1.9%, 1.9% and 1.9%, respectively) in healthy control subjects (all P-values were < 0.005). Forty-one (12.8%) OLP patients also had anti-hepatitis C virus antibody (HCVA) in their sera. The multivariate logistic regression found that major erosive OLP (EOLP) [odds ratio (OR) = 1.786], TGA/TMA-positivity (OR = 2.517), and HCVA-positivity (OR = 2.214) were significant risk factors to influence ANA-positivity in OLP patients. Moreover, only major EOLP (OR = 1.879) and ANA-positivity (OR = 2.581) were significant risk factors to influence TGA/TMA-positivity in OLP patients. Conclusions: There are significantly higher frequencies of presence of ANA, GPCA, TGA and TMA in Chinese OLP patients than in healthy control subjects. ? 2008 The Authors.Anti-hepatitis C virus antibody; Autoantibodies; Oral lichen planus[SDGs]SDG3antinuclear antibody; mitochondrion antibody; parietal cell antibody; smooth muscle antibody; thyroid antibody; virus antibody; adult; aged; antibody blood level; article; Chinese; controlled study; female; human; lichen planus; major clinical study; male; mouth lichen planus; priority journal; risk factor; Adult; Age Factors; Aged; Aged, 80 and over; Antibodies, Antinuclear; Autoantibodies; China; Diabetes Mellitus; Female; Hepatitis C Antibodies; Humans; Immunologic Factors; Lichen Planus, Oral; Male; Middle Aged; Mitochondria; Muscle, Smooth; Parietal Cells, Gastric; Risk Factors; Sex Factors; Thyroglobulin; Young Adultjournal article10.1111/j.1600-0714.2008.00686.x187648572-s2.0-58149163423