Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation

Hong, Chi-YuanChi-YuanHongSZE-KWAN LINYang, Cheng-NingCheng-NingYangCHIA-TUNG SHUNHAN-WEI WANGChen, Mu-HsiungMu-HsiungChenHUNG-YING LINHSIANG YANGEDDIE HSIANG HUA LAIWu, Fang-YuFang-YuWuSHIH-JUNG CHENGSANG-HENG KOK2023-09-042023-09-042023-07-1600992399https://scholars.lib.ntu.edu.tw/handle/123456789/635003We have previously demonstrated that auxiliary metformin therapy promotes healing of apical periodontitis. Here we aimed to investigate the effects of metformin on osteoblast differentiation and osteoclast formation in cultured cells and rat apical periodontitis.enApical periodontitis; hypoxia; metformin; receptor activator of nuclear factor-κB ligand; runt-related transcription factor 2; tartrate-resistant acid phosphataseMetformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiationjournal article10.1016/j.joen.2023.07.005374548722-s2.0-85166638050https://api.elsevier.com/content/abstract/scopus_id/85166638050