泌尿科CHENG, JEN-HAOJEN-HAOCHENGHUANG, A-MEIA-MEIHUANGHOUR, TZYH-CHYUANTZYH-CHYUANHOURYANG, SHYH-CHYUNSHYH-CHYUNYANGPU, YEONG-SHIAUYEONG-SHIAUPULIN, CHUN-NANCHUN-NANLIN2012-07-122018-07-112012-07-122018-07-112011http://ntur.lib.ntu.edu.tw//handle/246246/241703In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical- cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect.en-USXanthoneAntioxidationCytotoxicityReactive oxygen species[SDGs]SDG3