Hsiao S.-M.TING-CHEN CHANGHO-HSIUNG LIN2021-03-032021-03-0320190378-5122https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064738027&doi=10.1016%2fj.maturitas.2019.04.216&partnerID=40&md5=93a9efc958c7b5f84b632dc70fd6c1d4https://scholars.lib.ntu.edu.tw/handle/123456789/550157Objectives: The aim of this study is to compare the re-treatment probabilities after a 3-month versus a 6-month course of antimuscarinic treatment for women with overactive bladder syndrome (OAB). Study design: A prospective randomized controlled study. Main outcome measures: Between-group differences in the probability of re-treatment for OAB between the 3-month and 6-month groups. Methods: Women with OAB were randomly allocated to receive solifenacin (5 mg per day)for a treatment interval of either 3 or 6 months. Results: Ninety-one patients were treated in each group. The probability of re-treatment did not differ between the 3-month and 6-month groups (P = 0.11). Parity (hazard ratio = 1.81, P = 0.001), number of incontinence episodes (hazard ratio = 1.09, P = 0.008)and suboptimal response (hazard ratio = 3.56, P = 0.006)were independent predictors of re-treatment of OAB. Physical limitation, as indicated on the King's Health Questionnaire, was the only independent factor predicting completion of the scheduled treatment period (odds ratio = 1.01, P = 0.008). Conclusions: Prolonged antimuscarinic treatment does not decrease the need for re-treatment of OAB. Nonetheless, female patients with increased parity, more severe incontinence and a suboptimal response to antimuscarinic treatment are more likely to seek re-treatment of OAB due to recurrence of symptoms. In addition, patients with more serious physical limitation related to OAB are more likely to complete the scheduled treatment period. These findings could serve as a guide in clinical consultations regarding antimuscarinic treatment and if taken into consideration in future studies could lower the dropout rate. ? 2019 Elsevier B.V.[SDGs]SDG3solifenacin; muscarinic receptor blocking agent; solifenacin; urinary tract agent; adult; area under the curve; Article; controlled study; diagnostic test accuracy study; drug withdrawal; female; human; King Health Questionnaire; major clinical study; middle aged; overactive bladder; parity; prospective study; randomized controlled trial; receiver operating characteristic; retreatment; sensitivity and specificity; treatment response; urinary tract disease assessment; urine incontinence; aged; drug administration; overactive bladder; recurrent disease; retreatment; treatment outcome; Aged; Drug Administration Schedule; Female; Humans; Middle Aged; Muscarinic Antagonists; Recurrence; Retreatment; Solifenacin Succinate; Treatment Outcome; Urinary Bladder, Overactive; Urological Agentsjournal article10.1016/j.maturitas.2019.04.216312391112-s2.0-85064738027