H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cells

Ho, Pai-JiunPai-JiunHoMEN-LUH YENTang, Bo-ChungBo-ChungTangChen, Chiung-TongChiung-TongChenYen, B LinjuB LinjuYen2022-12-142022-12-142013-05-201523-08641557-7716https://scholars.lib.ntu.edu.tw/handle/123456789/626435Mesenchymal stem cells (MSCs) with multilineage differentiation capacity and immunomodulatory properties are novel sources for cell therapy. However, in vitro expansion of these rare somatic stem cells leads to senescence, resulting in declines of differentiation and proliferative capacities. We therefore investigated the mechanisms mediating senescence in human fetal MSCs termed placenta-derived multipotent cells (PDMCs).enPROTEIN-KINASE-C; CELLULAR SENESCENCE; MULTIPOTENT CELLS; ROS PRODUCTION; STROMAL CELLS; BONE-MARROW; EPITHELIAL-CELLS; IN-VITRO; AGE; SIRT1H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cellsjournal article10.1089/ars.2012.4692230882542-s2.0-84876104810WOS:000317478500001https://api.elsevier.com/content/abstract/scopus_id/84876104810