Yu H.-C.Lin C.-L.Chen Z.T.-Y.FUNG-RONG HUSung F.-C.I-JONG WANG2021-07-012021-07-0120141542-0124https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893778099&doi=10.1016%2fj.jtos.2013.08.003&partnerID=40&md5=0b77b486830232f8b8347ef2ff338ecbhttps://scholars.lib.ntu.edu.tw/handle/123456789/567264This study investigated the association between pterygium and skin cancer linking to ultraviolet (UV) radiation using claims data from 1997-2010, obtained from the Taiwan National Health Insurance Research Database. The study included 19,701 patients with pterygium and 78,804 sex- and age-frequency-matched comparison subjects. Multivariate Cox regression analyses were performed to assess the relationship between pterygium and risk of skin cancer by the end of 2010. The incidence rates of malignant melanoma (MM) and nonmelanoma skin cancer (NMSC) in two cohorts and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) of the diseases were measured. Results showed that the incidences of MM and NMSC were both higher in the pterygium cohort than in the comparison cohort (5.5 vs 3.2 and 32.3 vs 15.0 per 100,000 person years, respectively). After adjusting for age, sex, UV index, occupation, and the other comorbidities, pterygium remained a significant predictor of NMSC (hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.11-2.42), but not MM (HR, 1.46; 95% CI, 0.59-3.65). These results suggest that pterygium patients are associated with an increased risk of NMSC, but not significant for MM. ? 2014 Elsevier Inc. All rights reserved.Malignant melanoma; Pterygium; Skin cancer; Ultraviolet radiation[SDGs]SDG3adult; article; cancer incidence; cancer risk; cohort analysis; comorbidity; diabetes mellitus; female; human; major clinical study; male; melanoma; middle aged; parkinsonism; pterygium; retina macula age related degeneration; rheumatic disease; senile cataract; sun exposure; Taiwan; ultraviolet radiation; malignant melanoma; pterygium; skin cancer; ultraviolet radiation; Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Comorbidity; Female; Humans; Incidence; Male; Melanoma; Middle Aged; National Health Programs; Proportional Hazards Models; Pterygium; Risk Factors; Skin Neoplasms; Taiwan; Ultraviolet Rays; Young Adultjournal article10.1016/j.jtos.2013.08.003244390482-s2.0-84893778099