2020-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/651416摘要：精準醫學（precision medicine）是一種針對病患個別情形進行客製化醫療的醫學模式，近年來受到廣泛關注。智能型生醫材料之發展朝向精準醫學，因為其具有刺激-響應特性（例如pH、溫度及光響應特性），可以根據病患個別情形和材料的使用目的進行設計以達到最佳的治療效果。許多材料被發展用於製備智能型生醫材料，其中生物高分子具有良好的生物相容性和生物降解性，而合成材料具有良好的機械性質和智能特性。在先前的計畫中，本團隊已經合成具有光敏感性、熱敏感性、或形狀記憶性之水性聚胺酯。本計畫將進一步著重在聚胺酯之智能型生醫材料與生物高分子的結合。本計畫有三個研究標的：1）製備結合殼聚醣之智能型聚胺酯應用於可注射之自癒合水膠與冷凍凝膠；2）製備結合明膠之智能型聚胺酯應用於形狀記憶之支架材料；以及3）以細胞實驗（例如細胞活性和細胞分化）及動物實驗（例如大鼠神經修復和兔子軟骨修復模型）證明材料之生物相容性、生物活性及生物功能性。透過本計畫之執行，期望可以獲得最佳化材料、最佳化製造技術及透過動物實驗證實更佳之治療效果。<br> Abstract: Precision medicine, referring to the tailoring of medical treatment to the individual characteristics of each patient, has attracted wide attention in recent years. Smart biomaterials are developed towards precision medicine because these materials with stimuli-responsive properties (such as pH-, temperature- and lightresponsive properties) can be designed based on individual patients and medical applications for better therapies. Two categories of materials have been studied for fabrication of smart biomaterials, in which biopolymers show better biocompatibility, bioactivity, and biodegradability while synthetic polymers exhibit better mechanical properties and stimuli-responsive properties. Our group synthesized light-responsive, thermo-responsive and shape-memory polyurethanes in the previous years. In this project, we will focus on combinations of biopolymer and polyurethane and on fabrication of smart biomaterials. The special aims of this project include 1) combination of chitosan and polyurethane by synthesis for fabrication of injectable self-healing hydrogels or cryogels; 2) combination of gelatin and polyurethane by synthesis for the shape-memory scaffolds; and 3) evaluation for the biocompatibility, bioactivity, and biofunctionality of the materials via cellular experiments (such as cell viability and cell differentiation) and animal models (such as rat nerve repair and rabbit cartilage repair). Through the execution of this project, we expect that material preparations and manufacturing technologies are optimized, with better therapeutic effects substantiated via in vivo experiments.精準醫學聚胺酯生物高分子智能型水膠支架材料precision medicinepolyurethanebiopolymersmart hydrogelscaffold material