CHIEN-YI CHENPO-NIEN TSAOHUEY-LING CHENHUNG-CHIEH CHOUHsieh W.-S.MEI-HWEI CHANG2020-03-102020-03-1020040022-3476https://www.scopus.com/inward/record.uri?eid=2-s2.0-4444256601&doi=10.1016%2fj.jpeds.2004.05.038&partnerID=40&md5=d6e030305445cc26a14aac3f1b40881ehttps://scholars.lib.ntu.edu.tw/handle/123456789/475186Objective To determine the effect of ursodeoxycholic acid (UDCA) in very-low-birth-weight (VLBW) infants with parenteral nutrition-associated cholestasis (PNAC). Study design A retrospective study of all VLBW infants with PNAC who were admitted to a tertiary referral center was conducted. Patients were classified as treatment group (receiving UDCA within 14 days after onset of cholestasis) or control group (no medical treatment). Patients who received abdominal surgery were excluded. Results A total of 30 patients were recruited, including 12 in the treatment group and 18 in the control group. The demographic data, total fasting duration, onset of cholestasis, age to tolerance of full feeds, and the duration of parenteral nutrition (PN) before the onset of cholestasis were comparable between the two groups. There was a trend in the control group to later onset of cholestasis. The patients who received UDCA therapy with doses of 10 to 30 mg/kg/day had a shorter duration of cholestasis than the control group (62.8 vs 92.4 days, P=.006). Furthermore, the peak serum levels of direct bilirubin also was significantly lower in the treatment group. Conclusion UDCA can improve the course of PNAC in VLBW infants.English[SDGs]SDG3bilirubin; ursodeoxycholic acid; abdominal surgery; article; bilirubin blood level; cholestasis; clinical article; controlled study; demography; diarrhea; diet restriction; disease duration; drug effect; feeding; female; health center; hospital admission; human; infant; liver failure; male; nutritional tolerance; onset age; parenteral nutrition; patient referral; priority journal; very low birth weight; Bilirubin; Birth Weight; Case-Control Studies; Cholestasis; Female; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Male; Parenteral Nutrition; Retrospective Studies; Treatment Outcome; Ursodeoxycholic Acidjournal article10.1016/j.jpeds.2004.05.038153431822-s2.0-4444256601