HO-HSIUNG LINJIA-HORNG KAOLeu J. H.Young Y. C.Lee T. Y.PEI-JER CHENDING-SHINN CHEN2021-03-032021-03-0319930042-9007https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027257407&doi=10.1111%2fj.1423-0410.1993.tb02127.x&partnerID=40&md5=4ef30da464eae4ced946805c8c9865dfhttps://scholars.lib.ntu.edu.tw/handle/123456789/550291To compare different hepatitis C virus (HCV) immunoassays and HCV?RNA in pregnant women, we investigated two independent groups: 1,687 cases without screening for serum alanine aminotransferase (ALT) (group A) and 333 cases with elevated ALT (>45 IU/1) (group B), after screening 21,459 pregnant women. In group A, 11 (0.65%) and 21 (1.24%) were anti?HCV?positive by first? and second?generation tests, respectively, while in group B 8 (2.40%) and 19 (5.71%) were positive, respectively. The results revealed by second?generation assays based on either recombinant protein or synthetic peptides were identical, as were the anti?HCV titers in group B. Among 40 second?generation anti?HCV?positive cases, 18 (86%) of 21 in group A and 17 (89%) of the 19 in group B contained serum HCV?RNA by RT?PCR. Thus the prevalence of anti?HCV in Taiwanese pregnant women is 1.24% versus 5.71% in those with elevated ALT level. ? 1993 S. Karger AG, Basel[SDGs]SDG3alanine aminotransferase; antibody; recombinant protein; synthetic peptide; virus rna; alanine aminotransferase blood level; article; controlled study; female; hepatitis c; hepatitis c virus; human; immunoassay; intermethod comparison; normal human; polymerase chain reaction; pregnancy; prevalence; priority journal; screening; taiwan; virus detection; Comparative Study; Female; Hepacivirus; Hepatitis C; Human; Immunoassay; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; Support, Non-U.S. Gov't; Taiwanjournal article10.1111/j.1423-0410.1993.tb02127.x82126662-s2.0-0027257407