Association of Single-Nucleotide Polymorphism 3 and C.553g > T of Apoa5 with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in Hiv-Infected Individuals in Taiwan

醫學檢驗暨生物技術學系CHANG, SUI-YUANSUI-YUANCHANGKO, WEI-SHINWEI-SHINKOKAO, JAU-TSUENJAU-TSUENKAOLEE, CHUN-NANCHUN-NANLEESUN, HSIN-YUNHSIN-YUNSUNCHEN, MAO-YUANMAO-YUANCHENHSIEH, SZU-MINSZU-MINHSIEHSHENG, WANG-HUEIWANG-HUEISHENGCHANG, SHU-FANGSHU-FANGCHANGLIU, WEN-CHUNWEN-CHUNLIUWU, CHENG-HSINCHENG-HSINWUCHANG, SHAN-CHWENSHAN-CHWENCHANGKAO, CHUAN-LIANGCHUAN-LIANGKAOHUNG, CHIEN-CHINGCHIEN-CHINGHUNG2010-07-082018-07-062010-07-082018-07-062009http://ntur.lib.ntu.edu.tw//handle/246246/188808We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)- infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan. Receipt of protease inhibitor- based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP1T/SNP2G/SNP 3C/c.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia( triglyceride level, >500 mg/dL)en-US[SDGs]SDG3Association of Single-Nucleotide Polymorphism 3 and C.553g > T of Apoa5 with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in Hiv-Infected Individuals in Taiwan