Chou Y.-H.JA-DER LIANGWang S.-Y.SHIH-JER HSUHu J.-T.Yang S.-S.Wang H.-K.Lee T.-Y.Tiu C.-M.2021-02-182021-02-1820190929-6441https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068597411&doi=10.4103%2fJMU.JMU_44_19&partnerID=40&md5=36e6e82504fea21ffa932edec36945c1https://scholars.lib.ntu.edu.tw/handle/123456789/548917Background: The purpose of this study was to report the safety of perfluorobutane (Sonazoid) as a vascular-phase imaging agent in characterizing focal liver lesions (FLLs). Materials and Methods: From May 2014 to April 2015, a total of 54 individuals who received Sonazoid contrast-enhanced ultrasound (CEUS) were enrolled at 5 hospitals of 4 medical centers. All individuals were included in safety evaluation. A prospective study to evaluate the adverse effect (AE) incidences after intravenous administration of Sonazoid. Results: Sonazoid was well tolerated. Treatment-emergent adverse events (TEAEs) representing AE were recorded for 13 (24.1%) patients. The most common AE was abdominal pain (9.3%), followed by heart rate irregularity (5.6%). The majority of these patients (69.2%) experienced TEAEs that were mild in intensity. Sonazoid causes no significant AEs after intravenous injection. The only noteworthy AEs are related to tolerable myalgia (3.7%), abdominal pain (1.9%), and headache (1.9%). None of the 54 patients showed serious adverse effects. Conclusion: Sonazoid shows good safety and tolerance of intravenous use during CEUS of the liver for evaluation of FLLs. ? 2019 Journal of Medical Ultrasound | Published by Wolters Kluwer-Medknow.Contrast agent; focal liver lesions; microbubble; perfluorobutane; safety; Sonazoid; ultrasound[SDGs]SDG3perflubutane; abdominal pain; abnormal blood pressure; anemia; Article; contrast-enhanced ultrasound; drug safety; drug tolerability; female; gastrointestinal disease; headache; heart arrhythmia; heart rate; human; liver injury; major clinical study; myalgia; pancytopenia; phase 3 clinical trial; prospective study; vascular diseasejournal article10.4103/JMU.JMU_44_192-s2.0-85068597411