Tumor-Derived C-C Motif Ligand 2 Induces the Recruitment and Polarization of Tumor-Associated Macrophages and Increases the Metastatic Potential of Bladder Cancer Cells in the Postirradiated Microenvironment

YUN CHIANGYU-CHIEH TSAIWang, Chung-ChiehChung-ChiehWangFU-JEN HSUEHCHAO-YUAN HUANGChung, Shiu-DongShiu-DongChungCHUNG-HSIN CHENYEONG-SHIAU PUCHIA-HSIEN CHENG2022-11-072022-11-072022-100360-3016https://scholars.lib.ntu.edu.tw/handle/123456789/624459Radiation therapy (RT) is mainly used for bladder preservation in patients with muscle-invasive bladder cancer. The response of urothelial tumors to RT remains unsatisfactory. We investigated the interaction of RT and tumor-associated macrophages (TAMs) in the context of bladder cancer radioresistance.enPANCREATIC-CANCER; THERAPY; CCL2; RADIOTHERAPY; PHENOTYPE; RADIATION; VASCULOGENESIS; ANGIOGENESIS; IRRADIATION; INHIBITION[SDGs]SDG3Tumor-Derived C-C Motif Ligand 2 Induces the Recruitment and Polarization of Tumor-Associated Macrophages and Increases the Metastatic Potential of Bladder Cancer Cells in the Postirradiated Microenvironmentjournal article10.1016/j.ijrobp.2022.06.054356914492-s2.0-85136585092WOS:000864133400021https://scholars.lib.ntu.edu.tw/handle/123456789/624016