Huang L.-C.TZUNG-JENG HWANGHuang G.-H.Hwu H.-G.2020-10-232020-10-2320110929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955616413&doi=10.1016%2fS0929-6646%2811%2960014-4&partnerID=40&md5=b8bd57c25102ca11fecd0f04771f1e5chttps://scholars.lib.ntu.edu.tw/handle/123456789/517961Background/Purpose: Long-term outcome of patients with severe obsessive-compulsive disorder (OCD) and schizotypal features has been rarely studied. We investigated this issue in this retrospective pilot study. Methods: Twenty-two patients with severe OCD and schizotypal features were identified by chart review. Another 22 OCD patients without schizotypal features (OCD-NS) served as the comparison group. Those with schizotypal features must not fulfill a diagnosis of schizophrenia or schizotypal disorder. After an average follow-up of 6.6 years, each patient received a re-diagnosis clinical interview. Relevant demographic and clinical data were collected. Patients with schizotypal features were classified into two groups after rediagnosis: those with schizophrenia or schizotypal disorder (OCD-SS group, n = 9) and those with only schizotypal traits (OCD-ST group, n = 13) that did not fulfill a well-formed schizophrenia-spectrum disorder. Demographic data, family history, clinical symptoms, and OCD course were compared among the three patient groups. Results: Compared with the OCD-NS group, the OCD-SS group was significantly less educated, less likely to be married or female, and had earlier onset of illness and poorer OCD course (p < 0.05). There was no significant difference in any demographic and clinical variables between the OCD-SS and OCD-ST groups except that the OCD-ST group had a significantly better OCD course (p < 0.01). Conclusion: The findings suggest that a substantial proportion of the patients with severe OCD and schizotypal features evolve into schizophrenia spectrum disorder and are associated with a poor long-term outcome, whereas the OCD-NS group might stay with limited manifestations of schizotypal features and have a better outcome. ? 2011 Elsevier & Formosan Medical Association.Long-term outcome; Obsessive-compulsive disorder; Psychotic disorder; Schizophrenia; Schizotypal disorder[SDGs]SDG3adult; article; clinical article; clinical feature; controlled study; disease course; disease severity; follow up; human; information processing; obsessive compulsive disorder; outcome assessment; pilot study; schizophrenia; schizotypal personality disorderOutcome of severe obsessive-compulsive disorder with schizotypal features: A pilot studyjournal article10.1016/S0929-6646(11)60014-42-s2.0-79955616413