Chen, Chien-YuanChien-YuanChenTamiya, EETamiyaIshihara, KKIshiharaKosugi, YYKosugiSu, Y CY CSuNakabayashi, NNNakabayashiKarube, IIKarube2023-09-152023-09-151992-090273-2289https://www.scopus.com/record/display.uri?eid=2-s2.0-0026922505&doi=10.1007%2fBF02921780&origin=inward&txGid=a224062bfe0b8a9282e289866e272fc2https://scholars.lib.ntu.edu.tw/handle/123456789/635390A biocompatible needle-type glucose sensor with a 3-electrode configuration was constructed. A platinum-electroplated carbon stick was used as the working electrode, Ag/AgCl as the reference electrode, and a disposable hypodermic needle made of stainless steel as the counter electrode. A Nafion membrane, an immobilized glucose oxidase (GOD) membrane, and a biocompatible membrane with diffusion-limiting effect were coated successively onto the working electrode. The sensor showed a rapid response (< 120 s in batch operation), good reproducibility (RE < 3%), good stability (over 36 h in control serum), a wide dynamic range (5-600 mg/dL glucose), and superior biocompatibility. It was used to determine glucose in serum. The data obtained from the sensor showed good agreement with that from a clinical autoanalyzer (R > 0.95).en2-methacryloyloxyethyl phosphorylcholine (MPC) | Biocompatibility | cellulose triacetate (CTA) | diffusion-limiting effect | glucose oxidase | glucose sensor | n-butylmethacrylate (BMA) | needle type | serumjournal article10.1007/BF0292178012884102-s2.0-0026922505https://api.elsevier.com/content/abstract/scopus_id/0026922505