2018-01-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/699601摘要：本計畫的目標是開發可以經由3D列印的方式來建構之導電支架，利用導電高分子作為導電材材，結合氫氧磷灰石所形成之奈米複合材料，並混合聚乳酸及聚己內酯可之可分解高分子，以此支架作為骨頭再生之應用。骨頭再生的研究仍面臨幾個重要的挑戰，尤其在發展骨頭再生材料仍然有相當大的空間。目前市售的產品大都以磷酸鈣為主。雖然磷酸鈣提供良好之生物相容性及機械性質，但這類材料在加工上或是在臨床上的應用仍有很多限制。尤其這類材料需要高溫處理，限制了在材料上進行有機材料修飾或是生物分子改質的可能性，而這些方法正是促進細胞生長的關鍵。另一方面，最新的研究顯示，電刺激也可以加速骨頭細胞生長。因此，本計畫將開發以導電高分子為主之奈米複合材料，此材料不僅可以導電，並且可以用3D列印的方式成形，直接印製出想要支架之形狀進行骨頭再生。本計畫將分三個階段進行：第一階段是材料之合成與分析，實驗內容主要是合成多種導電高分子奈米複合材料，並分析導電高分子對於複合材料的影響，以及細胞在奈米複合材料上的表現；第二階段則針對此奈米複合材3D列印技術之開發，發展3D列印技術及設備，可直接列印成所需要之構造；第三個階段則是開發此3D支架之應用。 <br> Abstract: In this project, we aim to develop a 3D printable conducting materials based on conducting polymer-based nanocomposites. Besides the conducting polymers, these nanocomposites will be composed of some ceramics, such as hydroxyapatite, and biodegradable polymers, including poly(lactic-co-glycolic acid and polycaprolactone. The 3D scaffolds made by these nanocomposites will be used for bone regeneration. Until now, the bone regeneration still face several challenges. One of these is the development of osteoregenerative biomaterials. Currently, most of the products are composed of calcium phosphates. Although calcium phosphates are biocompatible and provide superior mechanical properties, the manufacturing process of these materials greatly limit the performance of their applications. Especially, the requirement of high temperature process prohibits these materials from surface modification by organic compounds or biomolecules, which is very critical for promoting cell growth. On the other hand, the newest studies have shown that the electrical stimuli also promote the cell growth. Therefore, we will develop conducting polymer-based nanocomposites, which allows not only the feasibility of electrical stimuli, but also 3D printing process. The 3D scaffold can be made directly for bone regeneration applications. There will be three phases of this project: In the first phase, the goal is to successfully develop the conducting polymer-based nanocomposites for 3D printing. Various nanocomposites of different composition will be synthesized for testing. The properties of these nanocomposites will be carefully evaluated, such as conductivity and mechanical properties. The cell compatibility and the behaviors will be examined, too. In the second phases, we will focus on the development of 3D printing process for the developed nanocomposites. The 3D printing system will be designed and manufactured. The properties of printed 3D scaffold will be evaluated, too. In the third phase, the research focus is the application of this conductive 3D scaffold.導電支架3D列印奈米複合材料功能性導電高分子conducting scaffold3D printingnanocompositefunctionalized conducting polymers