LI-HUI TSENGLin M.-T.Shau W.-Y.Lin W.-C.Chang F.-Y.KUO-LIONG CHIENHansen J.A.Chen D.-S.PEI-JER CHEN2021-07-032021-07-0320060001-2815https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984568783&doi=10.1111%2fj.1399-0039.2006.00536.x&partnerID=40&md5=a70b442608b7109bfdb0cd9c7f665e40https://scholars.lib.ntu.edu.tw/handle/123456789/568672Polymorphisms in cytokine genes can influence immune responses, inflammation and tissue injury, and may affect the outcome of hepatitis B virus (HBV) infection. We analyzed single nucleotide polymorphisms (SNP) in the interleukin (IL)-10 gene among 344 HBV carriers and 208 patients with hepatocellular carcinoma (HCC). Genotypes and haplotypes were tested for association with HCC. IL-10/-592 C/C genotype was associated with a higher risk for HCC compared with IL-10/-592 A/C and A/A genotypes [odds ratio (OR): 2.1, 95% confidence interval (CI): 1.2-3.6]. IL-10/1927 A/A genotype was also associated with a higher risk for HCC compared with IL-10/1927 A/C and C/C genotypes (OR: 1.5, 95% CI: 1.0-2.2). Haplotype analysis revealed that the homozygosity of the C-A haplotype (defined by SNPs at positions -592 and 1927) of IL-10 gene conveys the highest risk for HCC among HBV carriers compared with the homozygosity for the A-C haplotype (OR: 2.6, 95% CI: 1.3-4.9). The results demonstrate that IL-10 gene polymorphism can affect the outcome of chronic HBV infection. Further studies are necessary to clarify how variation in the IL-10 gene affects IL-10 function and risk of HCC. ? 2006 Blackwell Munksgaard.[SDGs]SDG3cytokine; interleukin 10; adult; aged; article; cancer risk; controlled study; genetic polymorphism; genetic variability; genotype; haplotype; hepatitis B; homozygosity; human; human cell; immune response; inflammation; liver cell carcinoma; major clinical study; nucleotide sequence; priority journal; single nucleotide polymorphism; Taiwan; tissue injury; Hepatitis B virusjournal article10.1111/j.1399-0039.2006.00536.x164414832-s2.0-84984568783