YEUN-CHUNG CHANGSSU-YUAN CHENTing L.-L.STEVEN SHINN-FORNG PENGWang T.-C.TYNG-GUEY WANG2021-03-192021-03-1920110003-9993https://scholars.lib.ntu.edu.tw/handle/123456789/554005Objective: To evaluate over a 2-year period the serial swallowing function of patients with nasopharyngeal carcinoma (NPC) after completing radiotherapy (RT). Design: Prospective longitudinal follow-up. Setting: University hospital. Participants: Patients with NPC (N=76) referred for RT: 53 of them at 1 year after RT, and 23 at 2 years after RT. Interventions: Not applicable. Main Outcome Measures: Participants completed a questionnaire and had a video-recorded fluoroscopic swallowing study before RT and 1 month, 1 year, and 2 years after RT. Results: The highest incidence of dysphagia symptoms and retropharyngeal soft tissue swelling occurred in the first month after RT and decreased over time. Pharyngeal transit time was prolonged continuously up to 1 year after RT. Epiglottic vallecular stasis and pharyngeal mucosal coating were worst in the first month after RT and stable afterwards. Aspiration was uncommon during the first 2 years after RT. Conclusions: At a 2-year follow-up after RT, patients with NPC had a progressively increasing pharyngeal transit time, although the subjectively identified symptoms of dysphagia decreased after the first month after RT. ? 2011 American Congress of Rehabilitation Medicine.[SDGs]SDG3cisplatin; epirubicin; fluorouracil; folinic acid; mitomycin; article; aspiration; cancer radiotherapy; dysphagia; edema; epiglottis; female; fluoroscopy; hospital; human; incidence; major clinical study; male; mucosa; nasopharynx; nasopharynx carcinoma; questionnaire; soft tissue; swallowing; symptom; videorecording; Adult; Deglutition; Deglutition Disorders; Female; Hospitals, University; Humans; Incidence; Male; Middle Aged; Nasopharyngeal Neoplasms; Prospective Studies; Radiation Injuriesjournal article10.1016/j.apmr.2011.06.008218405002-s2.0-80054995029