2005-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/685537摘要：目前已有證據顯示環境中同時有雄性激素干擾物質及雌性激素干擾物質存在，但是我們對於環境雄性激素干擾物質的現狀或對野生動物的影響尚不清楚，本計畫目的是發展一整合型魚類生物指標之生物測試方法來檢測環境中的雄性及雌性激素干擾物質。將選擇以測量雄性孔雀魚體表的橘色點大小，做為暴露到環境雄性激素的指標，再配合本研究室過去兩年已發展的測量孔雀魚體內卵黃前質(vitellogenin)含量做為暴露到環境雌性激素的指標。並將進一步探討在孔雀魚暴露到雄性激素或環境雄性激素，體內蝶酸(pteridine)合成的作用是否是一可能形成體表的橘色點增加的機制。<br> Abstract: There is increasing evidence showing that both environmental androgens and environmental estrogens presented in our surroundings. But little is known about the status of environmental androgens in our living environment and the effects of environmental androgens in wildlife. The objective of this study is to evaluate the usefulness of guppies as an integrated bioassay which can be used to detect both environmental androgens and environmental estrogens at the same time. The size of orange spots in male guppy is proposed to be used as an endpoint to detect environmental androgens and the induction of vitellogenin is used as an endpoint to detect environmental estrogens. In addition, the potential mechanism of increase orange pigments induced by testosterone and/or environmental androgens will be examined by pteridine biosynthesis pathway.孔雀魚環境雄性激素環境雌性激素卵黃前質蝶酸guppyenvironmental androgensenvironmental estrogensvitellogeninpteridine