CHIA-TER CHAOWang C.-Y.CHUN-FU LAITAO-MIN HUANGYEN-YUAN CHENKao T.-W.TZONG-SHINN CHUChang C.-H.VIN-CENT WUKo W.-J.Chen L.KWAN-DUN WU2019-12-252019-12-2520140171-5216https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899491777&doi=10.1007%2fs00432-014-1600-z&partnerID=40&md5=d435a3d182d6e9f739eaee3244b7831chttps://scholars.lib.ntu.edu.tw/handle/123456789/440510Background: Acute kidney injury (AKI) is gaining worldwide attention recently, emerging as a major public health threat. However, the association between the development of AKI and subsequent malignancy has not been studied before. Methods: We conducted a population study based on the Taiwan National Health Insurance database, using 1,000,000 representative database during 2000-2008. All patients' survival to discharge from index hospitalization with recovery from dialysis-requiring AKI were identified (recovery group), and matched with those without recovery and those without AKI, at a 1:1:1 ratio. Results: We identified 625 individuals more than 18 years old [352 male (56.5 %); mean age, 63.3 years] in recovery group and matched 625 individuals in each group. During a mean followed-up of 3.7 years, the incidences of new-onset malignancy were 4.2, 2.9, and 2.6 per 100 person-year among the non-recovery, the recovery, and the non-AKI group, respectively. After adjustment, the recovery group was more likely to develop long-term de novo malignancy than those without AKI [hazard ratio (HR) 1.44, 95 % confidence interval (CI) 1.02-2.03; p = 0.04], while less likely than those who did not recover (HR 0.66, 95 % CI 0.45-0.98; p = 0.04). Conclusions: Dialysis-requiring AKI can post a long-term risk of de novo malignancy for those who survive from the initial insult. Even patients who have recovered from dialysis still carry a significantly higher possibility of developing malignancy than those without AKI episode. ? 2014 Springer-Verlag.[SDGs]SDG3acute kidney failure; adult; aged; article; cancer risk; dialysis; female; follow up; hazard ratio; hospital discharge; hospitalization; human; incidence; major clinical study; male; population research; priority journal; survival; Taiwan; Acute Kidney Injury; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Hospitalization; Humans; Incidence; Male; Middle Aged; Neoplasms; Prognosis; Renal Dialysis; Risk Factors; Taiwanjournal article10.1007/s00432-014-1600-z245194902-s2.0-84899491777