AST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling

Shen, Wen-ChingWen-ChingShenYU-HSIANG CHOUShi, Li-ShianLi-ShianShiChen, Zhi-WeiZhi-WeiChenTu, Hai-JianHai-JianTuLin, Xin-YiXin-YiLinWang, Guei-JaneGuei-JaneWang2021-05-022021-05-0220211178-7031https://scholars.lib.ntu.edu.tw/handle/123456789/558421Acute kidney injury (AKI) is a devastating disorder associated with considerably high morbidity and mortality. Reports have shown that AST-120, an oral charcoal adsorbent, can reduce oxidative stress by lowering serum indoxyl sulfate levels. The effects of AST-120 and indoxyl sulfate on kidney injury and cardiac dysfunction were investigated in vivo and in vitro.enAST-120; NF-κB; acute kidney injury; apoptosis; cardiac dysfunction; inflammation[SDGs]SDG3ast 120; brain natriuretic peptide; indican; intercellular adhesion molecule 1; interleukin 1beta; nitrogen; urea; acute kidney failure; animal experiment; animal model; animal tissue; apoptosis; Article; blood level; blood sampling; cardiac muscle cell; clinical article; clinical effectiveness; cohort analysis; controlled study; creatinine blood level; down regulation; echocardiography; enzyme linked immunosorbent assay; heart failure; heart left ventricle ejection fraction; heart output; histopathology; human; human cell; in vitro study; in vivo study; inflammation; kidney function; liquid chromatography; mouse; NF kappaB ICAM 1 signaling; nonhuman; oxidative stress; reperfusion injury; signal transduction; treatment duration; TUNEL assay; umbilical vein endothelial cell; urea nitrogen blood level; Western blottingAST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signalingjournal article10.2147/JIR.S283378336588262-s2.0-85102189859https://scholars.lib.ntu.edu.tw/handle/123456789/558418