Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterization

Valdiviezo, AlanAlanValdiviezoBrown, Grace EGrace EBrownMichell, Ashlin RAshlin RMichellTrinconi, Cristiana MCristiana MTrinconiBodke, Vedant VVedant VBodkeKhetani, Salman RSalman RKhetaniYU-SYUAN LUOChiu, Weihsueh AWeihsueh AChiuRusyn, IvanIvanRusyn2022-12-052022-12-052022-110091-67651552-9924https://scholars.lib.ntu.edu.tw/handle/123456789/625876Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority chemicals subject to numerous human health risk evaluations by a range of agencies. Metabolism of TCE and PCE determines their ultimate toxicity; important uncertainties exist in quantitative characterization of metabolism to genotoxic moieties through glutathione (GSH) conjugation and species differences therein.enReanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterizationjournal article10.1289/EHP1200636445294