2023-01-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/649056植物先天免疫是防禦的第一道防線，經由辦認微生物共同之特有物質誘發稱作pattern-triggered immunity (PTI) 之防禦反應。近年已發現表觀遺傳調控機制參與植物與微生物之交互作用，然而，組蛋白去乙醯酶與乙醯酶在根部先天免疫反應之角色與調控分子機制卻全然未知。藉由本全體計畫之多元且互補之研究專長與累積之豐富研究資源，本子計畫將以模式植物阿拉伯芥與重要作物番茄為研究材料，針對其組蛋白去乙醯酶HDA6/15在逆境誘發之根部先天免疫反應之角色與調控分子機制進行深入研究與解析。藉由總計畫之統籌與合作、研究材料與資訊分享、集體腦力激盪等，我們預期將在基礎科研與農技應用上獲得更多新穎的關鍵知識，可有利於研發防治作物病害及抗逆之有效農業策略。 Plant innate immunity is the first layer of disease defense system and is triggered by specific recognition of microbial conserved molecular patterns, leading to pattern-triggered immunity (PTI) Epigenetic mechanisms are known to directly participate in modulation of plant-microbe interactions. However, roles of histone deacetylases (HDAs) in establishing plant immunity, particularly in root which is essential for plant survival and many biological functions, and possesses many unique features, remained to be explored. With the expertise and accumulated resources of the Main Project, this subproject aims to decipher epigenetic regulation of plant root innate immunity by studying functions of Arabidopsis thaliana and tomato HDA6/15 in root disease/symbiosis/PTI responses and epigenetic features modulated by drought and salinity. Through the integration of the Main Project, we expect to collectively gather important information and resources that may facilitate our future work on plant stress research and potentially on crop improvement as well.表觀遺傳;植物先天免疫;根;微生物;逆境;epigeneteics; plant innate immunity; root; microbes; stress