2014-12-082024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/681847摘要：啤酒花於啤酒釀造中作為保存及抑菌，同時增添風味、賦予啤酒特有的苦味，其特有的苦味酸被證實具有顯著抑制革蘭氏陽細菌生長的能力。近年研究發現其查耳酮黃腐酚(xanthohumol, XN)亦具有化學性促癌因子抑制劑、抗微生物感染等作用，顯見啤酒花萃取物具有開發相關生技產品的潛力。尋常性痤瘡及頭皮屑皆是常見的人類皮膚疾病，通常難以完全根治，其肇因是表皮常見伺機性微生物生長同時引發皮脂腺的過度分泌，促發宿主的自體免疫發炎反應，引起皮膚疾病。本研究將以啤酒花萃取物中有效的機能性成分，抑制痤瘡桿菌及皮屑芽孢菌的生長並求其抑制濃度，再以細胞培養法模擬人體皮膚生理機制，探討當抑制此二種微生物生長後，對抗皮膚發炎反應、皮脂分泌及角質細胞生長之調控性的影響。<br> Abstract: Hops, the female inflorescences of the hop plant (Humulus lupulus L.), are widely used in the brewing industry to add bitterness and aroma to beer. More recently, some flavanones and chalcones with prenyl or geranyl groups have been identified in hops and beers, and their biological activities of these compounds have been shown to possess various anti-bacterial, anti-inflammatory, anti-oxidative, anti-angiogenic, anti-melanogenic, anti-osteoporotic and anti-carcinogenic effects in the literature. Acne vulgaris and dandruff are the common skin diseases. The proliferation of bacteria such as Propionibacterium acnes, causing primary or secondary skin infections and follicular keratinization as well as inflammation, and Malassezia furfur, playing important roles in seborrheic dermatitis (SD) and dandruff (SD/D). To overcome the potential risk of adverse effects and antibiotic resistance from prescription medications, traditional herbal medicines have been extensively studied as alternative treatments for many diseases. This study is aimed to demonstrate the anti-microbial growth of P. acnes and M. furfur by the hop in cell model.啤酒花抗發炎抗菌性痤瘡皮屑芽孢菌Humulus lupulusant-inflammationanti-microbialacne vulgarisdandruff