外科Lee, Y.-C.Y.-C.LeeWu, C.-T.C.-T.WuLuh, S.-P.S.-P.LuhLee, J.-M.J.-M.LeeChen, C.-S.C.-S.ChenChang, Y.-L.Y.-L.Chang吳振都2009-01-082018-07-112009-01-082018-07-112000http://ntur.lib.ntu.edu.tw//handle/246246/96188Background: E-Cadherin is a subclass of the cadherin family that plays a major role in the maintenance of intercellular junctions in normal epithelium. Decreased expression of E- cadherin might be closely related to invasiveness and dedifferentiation in human cancers. This study is aimed at investigating the clinicopathological significance of E- cadherin expression and its impact on the prognosis in surgically resected non- small-cell lung cancer patients. Methods: Using immunohistochemical staining, the expression of E-cadherin was studied in 207 surgically resected lung cancer specimens from January 1990 through December 1994. The clinicopathological data and survival status were recorded and analysed against the E-cadherin expression level in each tumor. Results: E -cadherin expression was detected in 122 of the 207 lung tumors (59.0%), and the expression was significantly lower in tumors with poor differentiation (p<0.001), in tumors with vascular invasion( p<0.05), and in tumors with direct invasion into surrounding structures (p<0.01). There was no correlation between E- cadherin expression, and tumor stage and regional lymph-node metastasis. There was no significant difference in survival rate between higher (>40%) and lower (<40%) E- cadherin expression groups; however, in tumors 3 cm or less, a significant difference was found between higher and lower E- cadherin expressions (p<0 .0001). Conclusions: Underexpression of E-cadherin is associated with poor differentiation and invasiveness in NSCLC. In patients with small NSCLC ( less than or equal to3 cm), higher E-cadherin expression (>40 %) significantly had a favorable prognosis.en-USE-cadherinlung cancerLYMPH-NODE METASTASISADHESION MOLECULESCATENIN EXPRESSIONINVASIVENESS[SDGs]SDG3journal article