Liao, Tz-ShianTz-ShianLiaoChang, Pei-EnPei-EnChangChen, Yi-TingYi-TingChenChen, Ching-YiChing-YiChenChang, Cheng-Wei TomCheng-Wei TomChangYutakaTakemoto, JonJonYutakaTakemotoLin, Yuan-YuYuan-YuLin2025-07-102025-07-102025-04-3012121819https://www.scopus.com/record/display.uri?eid=2-s2.0-105005467695&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/730685This study aimed to evaluate the effect of mesobiliverdin IXα-enriched microalgae (MBV-SP) on growth, diarrhoea prevalence, intestinal morphology, antioxidant capacity, and inflammatory cytokines in lipopolysaccharide (LPS)-induced enteritis in weaned piglets. Seventy-two 28-day-old piglets were randomly divided into four groups: control (NC), LPS, tylosin, and MBV-SP, with saline/LPS (100 µg/kg) administered intraperitoneally on day 14. Results showed reduced mortality and diarrhoea rates in the tylosin + LPS and MBV-SP + LPS groups compared to the LPS group. Histological analysis revealed improved villus morphology and decreased crypt depth in the MBV-SP group. Catalase activity was notably higher in the MBV-SP group. Both tylosin and MBV-SP supplementation reduced pro-inflammatory cytokines, with MBV-SP exhibiting a more pronounced effect. In conclusion, MBV-SP mitigated diarrhoea, improved antioxidant capacity, and modulated inflammatory cytokines in weaned piglets with LPS-induced enteritis, highlighting its potential as a dietary supplement for the gut health in piglets.falselipopolysaccharidemesobiliverdin IXαmicroalgaeweaned piglets[SDGs]SDG2journal article10.17221/159/2024-cjas2-s2.0-105005467695